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Writer's pictureLabdhi Jain

Science of Psychedelics talk by David Luke




This is about Psilocybin mushrooms and LSD.

Research has revealed that the brain on drugs doesn't exhibit high activity; instead, there is a decrease in activity. So, why do we experience what we feel? The brain on psilocybin shows decreased activity but an increase in connectivity, indicating strong communication between diverse regions of the brain.




It is important to note that the setting in which LSD and Psilocybin are taken must be clinical or positive; otherwise, it could lead to anxiety and other negative symptoms. Moreover, because the brain continues to develop until the age of 25, individuals may experience more psychological problems during this period. While the brain never stops developing throughout life, it is considered fully developed at 25, making it easier to explore these substances after full development.


The systems are twisted in a way where cigarettes, known to be highly addictive and causing thousands of deaths, are legally sold. In contrast, there have been no reported deaths due to the overdose of Psilocybin mushrooms and LSD, both of which are illegal. These are the only drugs whose overdose won't result in fatality, and they are not addictive. The risks associated with using classical psychedelics clinically, including physiological, psychosis, suicide, and dependency risks, are low. There is a rare risk of HPPD (Hallucinogen Persisting Perception Disorder) with these drugs.


While LSD has been acknowledged for its contributions to music, art, and culture, there is less discussion about the scientific advancements facilitated by Psilocybin mushrooms and LSD.

  • A study from 1966 on mescaline creativity revealed various achievements, including a mathematical theorem for NOR gate circuits

  • a conceptual model of photons

  • a linear electron accelerator beam-steering device

  • a new design for the vibratory microtome

  • a technical improvement of the magnetic tape recorder

  • blueprints for private residences and an arts-and-craft shopping plaza

  • a space probe experiment designed to measure solar properties


Amerindians believe in "turning into things you want to study." Relevant book references on this topic include "Entangled Life" by Merlin and "The Cosmic Serpent: DNA and the Origins of Knowledge" by Jeremy Narby.



Research has shown that individuals experiencing mystical experiences (connection with the universe, divine energy) have a low risk of clinical depression and anxiety. Repression of emotions reduces the likelihood of mystical experiences. A hundred percent of people feel connected to nature in some way, and 60% of people show an increase in concern for nature. Numerous studies indicate that taking Psilocybin mushrooms has helped people quit smoking cigarettes.











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